Best Upsets from the NCAA Baseball Regionals So Far

True college sports fans know the best things happen in the postseason. Energy is up, stakes are high, and anything can happen. There is nothing like a postseason upset to get fans fired up. College baseball may have the highest stakes of any postseason in college athletics. In just one weekend the top 64 teams in the country are narrowed down to just 16. The 2025 college baseball season has been unpredictable in itself, the preseason number one seed, Texas A&M, fell so far out of the rankings that they didn’t even make it into a regional to start the postseason. The Postseason ball has been electric and unpredictable as expected after three days of play. Let’s break down some of the best upsets of the regional weekend.

East Carolina at Florida:

The ECU Pirates have had a historically rough season. A team that is usually ranked in the top 25 all season long didn’t even scratch the surface of that 25th-seed ranking. However, they pulled through when it was necessary. Taking the American Athletic Conference title they snuck their way into the Conway Regional. After the season they’ve had it was expected the Pirates would fall to their SEC opponent the Florida Gators in their first regional game. However, the Pirates had other plans.

Pitcher Ethan Norby held the Gators batters to only two runs for most of the game. ECU’s offense was on fire, putting up 11 runs on the Gator's pitching staff. Even when Norby ran out of steam allowing the Gators to attempt to rally it wasn’t enough. Scoring early and often gave the Pirates the advantage to push them forward into the winner's bracket. Despite a brutal loss to Coastal Carolina on May 31st, the Pirates offense was not done yet. The Pirates then came back on June 1st and put up 11 more runs against the Gator’s pitching staff to claw themselves back out of the loser’s bracket and into the championship series against Coastal. 

West Virginia at Clemson:

Clemson has been not just an ACC powerhouse but a top 25 nationally ranked powerhouse all season. They sat comfortably in the top 25 for weeks leading up to the postseason only to start to fall when it mattered most. After getting swept by NC State in a regular season series it seemed the Tigers were unable to find their footing. Despite being selected to host a regional they slipped into the losers bracket after falling in their second regional game, 9-6, to West Virginia. 

Kentucky at Clemson: 

Following their loss to WVU, things just got worse for the Tigers. In their losers bracket matchup against Kentucky, it was all Wildcats. The Kentucky Wildcats dominated, determined to pull themselves into the championship game. Clemson’s defense struggled to hold off the Kentucky batters allowing a total of 16 runs to be scored by the Wildcats. In addition to their struggling defense Clemson's batting lineup struggled against the Wildcat defense and pitching staff and fell behind early. Once ranked third in the nation, Clemson’s road to Omaha ended on May 31st with a massive 16-4 loss. 

Wright State at Vanderbilt:

Vanderbilt has fallen victim to the curse of SEC bias. The former one-seed, fell into the losers bracket after a loss to Louisville in their second game of the weekend. Wright State was determined to pull themselves out of the losers bracket putting up four runs against Vanderbilt’s defense in just the first inning. While Vandy did try to rally with three runs in the final inning it was so close but not enough. The one seed has been dethroned and Wright State will face Louisville in the final game of the series on Monday. 

UTSA at Texas: 

The fall of SEC baseball did not end with Vandy. The two-seed Texas was upset not once but twice by the AAC’s UTSA. The Roadrunners first took down the Longhorns 9-7 in the winner's bracket on May 31st. Two games back-to-back on Sunday must’ve taken it out of the Longhorns because after defeating Kansas State by a massive score of 15-8, they then allowed UTSA to take them down for a second time 7-4. The two seed has been eliminated and the Roadrunners will be moving on to a super-regional.